The Twin Brains
What happens when GBA Homeostasis is disrupted?
Chronic inflammation is reinforced by signals from the brain, which leads to the recruitment of additional immune cells such as macrophages, mast cells, neutrophils, and several other cell types. This ultimately results in mucosal barrier damage, altered permeability, and, over time, can lead to fibrosis and is often accompanied with neuropsychological symptoms. For example, ulcerative colitis and Irritable bowel syndrome include symptoms of diarrhea or constipation, bleeding, and abdominal pain, as well as depression, anxiety, or cognitive impairment.